Extracting Microvolt Nerve Signals in the Presence of Large Stimulation Artifacts

Core clinical engineering and protocols for Neural Artifact Suppression.

The Extreme Dynamic Range Disparity in Neural Engineering

Peripheral nerve action potentials measure only 1 to 10 microvolts, while adjacent muscular electromyographic (EMG) signals measure in millivolts and electrical stimulation pulses reach several volts. Attempting to record nerve intent during active stimulation easily saturates sensitive bio-amplifiers.

Active Hardware Artifact Blanking Circuits

NeuroLiaison incorporates specialized mixed-signal ASIC architectures with rapid artifact blanking switches: the recording front-end is physically disconnected for hundreds of microseconds during the stimulation pulse, recovering to baseline in under 1 millisecond to capture subsequent natural neural spikes.

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